Ruiz DE Luzuriaga Arlene M, Hsieh Clifford
University of Chicago, Department of Medicine, Section of Dermatology, Chicago, Illinois;
University of Chicago Pritzker School of Medicine, Chicago, Illinois.
J Clin Aesthet Dermatol. 2015 Mar;8(3):16-9.
To examine the skin cancer tumor accrual rates in non-Caucasian and Caucasian post-transplant recipients.
DESIGN/SETTING/PARTICIPANTS: Retrospective chart review of solid-organ transplant patients who presented to the outpatient dermatology clinic at the University of Chicago and have had at least one skin biopsy to rule in/out skin cancer in the 10-year period from January 1, 2003, to December 31, 2012. One hundred fifty-two solid-organ transplant recipients were identified through a natural language search in CoPathPlus.
Each transplant patient's skin cancer accrual rates, defined as the number of skin cancers per person per year, were examined. The average accrual rates for non-Caucasians and Caucasians were compared and analyzed.
Of the 152 post-transplant patients identified, 58 were non-Caucasian and 94 were Caucasian. Eight (13.8%) non-Caucasians developed skin cancer, compared to 61 (64.9%) Caucasians (P< 0.001). Non-Caucasian post-transplant patients had lower skin cancer accrual rates with an overall skin cancer accrual rate of 0.13, squamous cell carcinoma accrual rate of 0.10, and basal cell carcinoma accrual rate of 0.01 versus 1.13 (P< 0.001), 0.96 (P< 0.001), and 0.15 (P< 0.001), respectively, for Caucasian patients. Comparison of post-transplant non-Caucasian and Caucasian patients who developed skin cancer revealed lower overall (0.96 vs. 1.74; P=0.25), squamous cell carcinoma (0.75 vs. 1.49; P=0.16), and basal cell carcinoma (0.06 vs. 0.24; P=0.13) accrual rates in non-Caucasians.
The authors' findings highlight the importance of annual total body skin exams for post-transplant patients and the need to identify and further educate those transplant patients with a higher risk for skin cancer development.
研究非白种人和白种人移植后受者的皮肤癌肿瘤累积发生率。
设计/地点/参与者：对2003年1月1日至2012年12月31日这10年间到芝加哥大学门诊皮肤科就诊且至少接受过一次皮肤活检以确诊/排除皮肤癌的实体器官移植患者进行回顾性病历审查。通过在CoPathPlus中进行自然语言搜索，确定了152名实体器官移植受者。
检查每位移植患者的皮肤癌累积发生率，定义为每人每年的皮肤癌数量。比较并分析非白种人和白种人的平均累积发生率。
在确定的152名移植后患者中，58名是非白种人，94名是白种人。8名（13.8%）非白种人发生了皮肤癌，而白种人有61名（64.9%）（P<0.001）。非白种人移植后患者的皮肤癌累积发生率较低，总体皮肤癌累积发生率为0.13，鳞状细胞癌累积发生率为0.10，基底细胞癌累积发生率为0.01，而白种人患者分别为1.13（P<0.001）、0.96（P<0.001）和0.15（P<0.001）。对发生皮肤癌的移植后非白种人和白种人患者进行比较，发现非白种人的总体（0.96对1.74；P=0.25）、鳞状细胞癌（0.75对1.49；P=0.16）和基底细胞癌（0.06对0.24；P=0.13）累积发生率较低。
作者的研究结果凸显了对移植后患者进行年度全身皮肤检查的重要性，以及识别并进一步教育那些皮肤癌发生风险较高的移植患者的必要性。
