单剂量奎宁引发的肾局限性血栓性微血管病和急性间质性肾炎。

Renal-limited thrombotic microangiopathy and acute interstitial nephritis with a single dose of quinine.

作者信息

Anjelo Jobert, Rao Nitesh, David Vinoi G, Otto Sophia, Russ Graeme

机构信息

Central Northern Adelaide Renal Transplantation Services , Royal Adelaide Hospital , Adelaide , Australia ; Division of Nephrology , Royal Adelaide Hospital , Adelaide, SA , Australia.

Central Northern Adelaide Renal Transplantation Services , Royal Adelaide Hospital , Adelaide , Australia.

出版信息

Clin Kidney J. 2014 Jun;7(3):311-3. doi: 10.1093/ckj/sfu035. Epub 2014 May 7.

DOI:10.1093/ckj/sfu035

PMID:25852897

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4377755/

Abstract

Quinine has been reported to cause acute kidney injury by various mechanisms. The response to quinine can result in a spectrum of problems ranging from isolated thrombocytopenia to thrombotic microangiopathy (TMA) to disseminated intravascular coagulation. Quinine has also been reported to cause acute interstitial nephritis (AIN). We report an unusual presentation where both of these entities of renal-limited TMA and AIN were precipitated by a single dose of quinine.

摘要

据报道，奎宁可通过多种机制导致急性肾损伤。对奎宁的反应可能会引发一系列问题，从孤立性血小板减少到血栓性微血管病（TMA），再到弥散性血管内凝血。也有报道称奎宁可导致急性间质性肾炎（AIN）。我们报告了一例罕见病例，单次服用奎宁引发了局限于肾脏的TMA和AIN这两种情况。