Roy Bhaskar, Dwivedi Yogesh
Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Neurosci Biobehav Rev. 2017 Jan;72:10-27. doi: 10.1016/j.neubiorev.2016.10.031. Epub 2016 Nov 9.
Current understanding of environmental cross-talk with genetic makeup is found to be mediated through an epigenetic interface which is associated with prominent reversible and heritable changes at gene expression level. Recent emergence of epigenetic modulation in shaping the genetic information has become a key regulatory factor in answering the underlying complexities associated with several mental disorders. A comprehensive understanding of the pertinent changes in the epigenetic makeup of suicide phenotype exhibits a characteristic signature with the possibility of using it as a biomarker to help predict the risk factors associated with suicide. Within the scope of this current review, the most sought after epigenetic changes of DNA methylation and histone modification are thoroughly scrutinized to understand their close functional association with the broad spectrum of suicide phenotype.
目前发现，对环境与基因组成相互作用的理解是通过一个表观遗传界面介导的，该界面与基因表达水平上显著的可逆和可遗传变化相关。表观遗传调控在塑造遗传信息方面的最新出现，已成为回答与几种精神障碍相关的潜在复杂性问题的关键调节因素。对自杀表型表观遗传组成相关变化的全面理解展现出一种特征性标志，有可能将其用作生物标志物来帮助预测与自杀相关的风险因素。在本综述范围内，对最受关注的DNA甲基化和组蛋白修饰的表观遗传变化进行了深入研究，以了解它们与广泛的自杀表型的密切功能关联。
