Chaichana Kaisorn L, Pinheiro Leon, Brem Henry
Department of Neurosurgery, Johns Hopkins University School of Medicine, 1800 Orleans Street, Zayed 6007B, Baltimore, MD 21202, USA.
Ther Deliv. 2015 Mar;6(3):353-69. doi: 10.4155/tde.14.114.
Malignant gliomas, including glioblastoma and anaplastic astrocytomas, are characterized by their propensity to invade surrounding brain parenchyma, making curative resection difficult. These tumors typically recur within two centimeters of the resection cavity even after gross total removal. As a result, there has been an emphasis on developing therapeutics aimed at achieving local disease control. In this review, we will summarize the current developments in the delivery of local therapeutics, namely direct injection, convection-enhanced delivery and implantation of drug-loaded polymers, as well as the application of these therapeutics in future methods including microchip drug delivery and local gene therapy.
恶性胶质瘤,包括胶质母细胞瘤和间变性星形细胞瘤,其特征在于易于侵袭周围脑实质,这使得根治性切除变得困难。即使在大体全切后,这些肿瘤通常也会在切除腔两厘米范围内复发。因此,一直强调开发旨在实现局部疾病控制的治疗方法。在本综述中,我们将总结局部治疗方法的当前进展,即直接注射、对流增强递送和载药聚合物植入,以及这些治疗方法在未来方法中的应用,包括微芯片药物递送和局部基因治疗。