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2
Noninvasive disruption of the blood-brain barrier in the marmoset monkey.非侵入性破坏狨猴血脑屏障。
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3
BBB opening with focused ultrasound in nonhuman primates and Parkinson's disease patients: Targeted AAV vector delivery and PET imaging.在非人灵长类动物和帕金森病患者中使用聚焦超声打开 BBB:靶向 AAV 载体传递和 PET 成像。
Sci Adv. 2023 Apr 21;9(16):eadf4888. doi: 10.1126/sciadv.adf4888. Epub 2023 Apr 19.
4
Efficacy of gene delivery to the brain using AAV and ultrasound depends on serotypes and brain areas.使用 AAV 和超声将基因递送到大脑的效果取决于血清型和大脑区域。
J Control Release. 2022 Nov;351:667-680. doi: 10.1016/j.jconrel.2022.09.048. Epub 2022 Oct 6.
5
Multimodal analyses of a non-human primate model harboring mutant amyloid precursor protein transgenes driven by the human EF1α promoter.携带人 EF1α 启动子驱动的突变淀粉样前体蛋白转基因的非人类灵长类动物模型的多模态分析。
Neurosci Res. 2022 Dec;185:49-61. doi: 10.1016/j.neures.2022.08.008. Epub 2022 Sep 6.
6
Therapeutic Agent Delivery Across the Blood-Brain Barrier Using Focused Ultrasound.利用聚焦超声实现血脑屏障内治疗药物的递送。
Annu Rev Biomed Eng. 2021 Jul 13;23:89-113. doi: 10.1146/annurev-bioeng-062117-121238. Epub 2021 Mar 22.
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Generation of Common Marmoset Model Lines of Spinocerebellar Ataxia Type 3.3型脊髓小脑共济失调普通狨猴模型系的建立
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Viral Vectors for Neural Circuit Mapping and Recent Advances in Trans-synaptic Anterograde Tracers.病毒载体用于神经回路映射和跨突触顺行示踪剂的最新进展。
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9
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Delivery of local therapeutics to the brain: working toward advancing treatment for malignant gliomas.将局部治疗药物递送至脑部:致力于推进恶性胶质瘤的治疗
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聚焦超声介导病毒神经元示踪剂在狨猴中的传递。

Focused ultrasound-mediated delivery of viral neuronal tracers in marmosets.

机构信息

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Cell Rep Methods. 2024 Feb 26;4(2):100719. doi: 10.1016/j.crmeth.2024.100719.

DOI:10.1016/j.crmeth.2024.100719
PMID:38412835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10921033/
Abstract

In this issue of Cell Reports Methods, Parks et al. present an approach to non-invasively deliver adeno-associated viruses in a marmoset model using focused ultrasound (FUS) for neuronal tracing. The optimization of this technique in this non-human primate model is highly valuable for future FUS-mediated drug delivery studies.

摘要

在本期《细胞报告方法》中,Parks 等人提出了一种使用聚焦超声(FUS)在狨猴模型中进行非侵入性传递腺相关病毒用于神经元示踪的方法。该技术在这种非人类灵长类动物模型中的优化对于未来的 FUS 介导的药物递送研究具有非常重要的价值。