Paldor Iddo, Chaichana Kaisorn L, Brem Henry, Tyler Betty M
Prog Neurol Surg. 2018;32:159-171. doi: 10.1159/000469688. Epub 2018 Jul 10.
Systemic chemotherapy of malignant brain tumors has failed to achieve sufficient drug concentrations at the neoplasm site and frequently results in severe toxicities. Therefore, the local application of several anticancer agents, oncolytic viruses and vectors for gene therapy, immune-modifying preparations, and angiogenesis inhibitors has been investigated widely. Various modes of their administration were introduced, including intratumoral injections, implantation of reservoirs or pumps, convection-enhanced delivery, and use of nanocarriers, thermoreversible gels, microchips, and drug-loaded polymers. Many of these therapeutic approaches have shown promising results in management of high-grade gliomas.
恶性脑肿瘤的全身化疗未能在肿瘤部位达到足够的药物浓度，且常常导致严重的毒性反应。因此，人们广泛研究了几种抗癌药物、溶瘤病毒、基因治疗载体、免疫调节制剂和血管生成抑制剂的局部应用。引入了多种给药方式，包括瘤内注射、储库或泵的植入、对流增强递送以及使用纳米载体、热可逆凝胶、微芯片和载药聚合物。这些治疗方法中的许多在高级别胶质瘤的治疗中已显示出有前景的结果。
