Yang Dongxu, Li Dan, Wang Linqing, Zhao Depeng, Wang Rui
†Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou 730000, People's Republic of China.
§Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China.
J Org Chem. 2015 May 1;80(9):4336-48. doi: 10.1021/acs.joc.5b00013. Epub 2015 Apr 22.
The successful design and application of a new type of N-phenyl-imidazole-modified α-heteroatom ketones in asymmetric anti-selective Michael reactions with β-trans-nitroalkenes is reported. High yields and enantioselectivities could be obtained, and the corresponding conjugate adducts could be further transformed into related chiral esters and cyclopropane derivatives with excellent enantioselectivities.
报道了一种新型N-苯基咪唑修饰的α-杂原子酮在与β-反式硝基烯烃的不对称反选择性迈克尔反应中的成功设计与应用。可以获得高产率和对映选择性，并且相应的共轭加合物可以进一步转化为具有优异对映选择性的相关手性酯和环丙烷衍生物。
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