Graduate School for Integrative Sciences & Engineering (NGS), Centre for Life Sciences (CeLS), National University of Singapore, #05-01, 28 Medical Drive, 117456 Singapore.
Org Biomol Chem. 2015 Feb 28;13(8):2350-9. doi: 10.1039/c4ob02486a.
α-Fluoro-α-nitro esters were used as reaction partners in Michael addition to nitroalkenes, and the products were obtained in excellent chemical yields and with high enantioselectivities. Moreover, α-fluoro-α-amino ester with a quaternary α-carbon was prepared for the first time.
α-氟-α-硝基酯被用作迈克尔加成反应的亲电试剂与硝基烯烃反应，产物以极好的化学收率和高对映选择性得到。此外，首次制备了具有季碳的α-氟-α-氨基酯。
