通过烯丙基磺酰胺与胺的顺序反应实现高度取代咪唑的区域选择性合成。
Regioselective Synthesis of Highly Substituted Imidazoles via the Sequential Reaction of Allenyl Sulfonamides and Amines.
作者信息
Yu Lian, Deng Yuan, Cao Jian
机构信息
Key Laboratory of Organosilicon Chemistry and Material Technology of the Ministry of Education, Hangzhou Normal University, Wenyi Road 222, Hangzhou 310012, People's Republic of China.
出版信息
J Org Chem. 2015 May 1;80(9):4729-35. doi: 10.1021/acs.joc.5b00141. Epub 2015 Apr 17.
PMID:25853897
Abstract
A novel synthesis of imidazoles from electron-withdrawing group-substituted allenyl sulfonamides with amines was developed. The 4- and 5-functionalized imidazoles were constructed regioselectively, which depended on the substituents on the nitrogen atoms.
摘要
开发了一种由吸电子基团取代的烯丙基磺酰胺与胺合成咪唑的新方法。4-和5-官能化的咪唑通过区域选择性构建，这取决于氮原子上的取代基。
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