Department of Obstetrics and Gynaecology, Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, China.
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Front Endocrinol (Lausanne). 2022 May 4;13:873286. doi: 10.3389/fendo.2022.873286. eCollection 2022.
In the past decade, the incidence of recurrent pregnancy loss (RPL) has increased significantly, and immunological disorders have been considered as one of the possible causes contributing to RPL. The presence of antinuclear antibodies (ANAs) is regarded as a typical antibody of autoimmunity. However, the relationship between the presence of ANAs and RPL, the underlying mechanism, and the possible role of immunotherapy is still controversial. The aim of this mini review is to assess the association between ANAs and RPL and the effects of immunotherapy on pregnancy outcomes in women with positive ANAs and a history of RPL from the available data and to provide a relevant reference basis for clinical application in this group of women.
在过去的十年中，复发性妊娠丢失（RPL）的发病率显著增加，免疫紊乱被认为是导致 RPL 的可能原因之一。抗核抗体（ANA）的存在被认为是自身免疫的典型抗体。然而，ANA 的存在与 RPL 之间的关系、潜在机制以及免疫治疗的可能作用仍存在争议。本综述的目的是评估来自现有数据的 ANA 阳性且有 RPL 病史的女性中，ANA 与 RPL 之间的相关性以及免疫治疗对妊娠结局的影响，并为该组女性的临床应用提供相关参考依据。
