贝米肝素在不明原因死胎后的预防作用：开放标签干预性前瞻性研究。
Bemiparin as a Prophylaxis After an Unexplained Stillbirth: Open-Label Interventional Prospective Study.
机构信息
Department of Obstetrics and Gynecology, Kurdistan Board of Medical Specialty, Erbil, Kurdistan, Iraq.
Department of Obstetrics and Gynecology, College of Medicine, Hawler Medical University, Erbil, Kurdistan, Iraq.
出版信息
Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029619896629. doi: 10.1177/1076029619896629.
Stillbirth is a devastating event to the parents, relatives, friends, and families. The role of anticoagulants in the prevention of unexplained stillbirths is uncertain. An open-label interventional prospective cohort study was conducted on 144 women with a history of unexplained stillbirths. The intervention group had a high umbilical artery resistance index (RI) and received bemiparin. The nonintervention group had a normal RI and did not receive any intervention. We measured the adjusted odds ratio (OR) and 95% confidence interval (CI) of the main outcome for these variables using logistic regression analysis. Fresh stillbirth and early neonatal death rates were lower ( = .005, OR = 11.949 and 95% CI = 2.099-68.014) and newborn weight was higher ( = .015, OR = 0.048, 95% CI = 0.004-0.549) in the group that received bemiparin. Bemiparin is effective in decreasing the rate of stillbirth in women with a history of previous unexplained stillbirths.
死胎对父母、亲属、朋友和家庭来说是一个毁灭性的事件。抗凝剂在预防不明原因的死胎中的作用尚不确定。对 144 名有不明原因死胎史的妇女进行了一项开放性、干预性前瞻性队列研究。干预组的脐动脉阻力指数（RI）较高，接受贝米肝素治疗。非干预组 RI 正常，未接受任何干预。我们使用逻辑回归分析测量了这些变量的主要结果的调整优势比（OR）和 95%置信区间（CI）。新鲜死胎和早期新生儿死亡率较低（ =.005，OR = 11.949，95% CI = 2.099-68.014），新生儿体重较高（ =.015，OR = 0.048，95% CI = 0.004-0.549）在接受贝米肝素的组中。贝米肝素可有效降低有既往不明原因死胎史的妇女的死胎发生率。
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