Ghafouri-Fard Soudeh
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran E-mail :
Asian Pac J Cancer Prev. 2015;16(7):3079-81. doi: 10.7314/apjcp.2015.16.7.3079.
Cancer-testis antigens (CTAs) are a group of tumor associated antigens with a restricted expression pattern in normal gametogenic tissues but expression in a broad range of malignancies. Their expression pattern has made them potential targets for immunotherapy. However, expression of some of these antigens has been demonstrated in normal stem cells as well as cancer stem cells (CSCs). As CSCs have been shown to be sources of metastasis and tumor recurrence, novel therapies are being focused on their eradication. On the other hand, CTA expression in normal stem cells raises the possibility that CTA based immunotherapies cause side effects in normal tissues.
癌-睾丸抗原（CTAs）是一组肿瘤相关抗原，在正常生精组织中表达模式受限，但在多种恶性肿瘤中表达。它们的表达模式使其成为免疫治疗的潜在靶点。然而，已证实其中一些抗原在正常干细胞以及癌症干细胞（CSCs）中也有表达。由于癌症干细胞已被证明是转移和肿瘤复发的来源，新型疗法正聚焦于根除它们。另一方面，正常干细胞中CTA的表达增加了基于CTA的免疫疗法在正常组织中产生副作用的可能性。
