Tsouana Eva, Stoneham Sara, Fersht Naomi, Kitchen Neil, Gaze Mark, Bomanji Jamshed, Fraioli Francesco, Hargrave Darren, Shankar Ananth
Department of Pediatric & Adolescent Oncology, University College London Hospitals NHS Foundation Trust, UK.
Department of Oncology, University College London Hospitals NHS Foundation Trust, UK.
Pediatr Blood Cancer. 2015 Sep;62(9):1661-3. doi: 10.1002/pbc.25538. Epub 2015 Apr 8.
The efficacy of hybrid 18F-Fluroethyl-Choline (FEC) positron emission tomography (PET)/magnetic resonance imaging (MRI) was investigated as an imaging modality for diagnosis and assessment of treatment response and remission status in four patients with proven or suspected intracranial non-germinomatous germ cell tumours (NGGCT). In two patients faint or absent choline avidity correlated with negative histology, whereas in other two patients, persistent choline avidity in the residual mass was suggestive of presence of viable tumour, subsequently confirmed histologically. We conclude that FEC-PET/MRI may be an effective imaging tool in detecting viable residual tumour in patients with intracranial NGGCT post treatment.
对4例已证实或疑似颅内非生殖细胞瘤性生殖细胞肿瘤（NGGCT）患者，研究了混合18F-氟乙基胆碱（FEC）正电子发射断层扫描（PET）/磁共振成像（MRI）作为诊断、评估治疗反应及缓解状态的成像方式的有效性。2例患者胆碱摄取微弱或无摄取与组织学阴性相关，而另外2例患者残余肿块中持续存在胆碱摄取提示有存活肿瘤，随后经组织学证实。我们得出结论，FEC-PET/MRI可能是检测颅内NGGCT患者治疗后存活残余肿瘤的有效成像工具。
