Thompson Nicola, Storr Sarah, Zhang Siwei, Martin Stewart
University of Nottingham, Department of Clinical Oncology, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, UK.
Histol Histopathol. 2015 Sep;30(9):1001-9. doi: 10.14670/HH-11-615. Epub 2015 Apr 9.
The presence of lymphovascular invasion is a recognised poor prognostic factor in a wide range of tumour types. Vascular invasion was historically identified through haematoxylin and eosin staining, however this technique is non-specific and differentiates poorly between blood and lymphatic vessels. Newer techniques using immunohistochemistry allow more sensitive and specific identification of lymphovascular invasion and are able to accurately differentiate between lymphatic and blood vessels. This review will discuss the current methods available for the assessment of lymphovascular invasion. Additionally, it will focus on the role of lymphovascular invasion in breast cancer and melanoma, discussing the relative importance of lymphatic and blood vessel invasion in each tumour type.
在多种肿瘤类型中，淋巴管浸润的存在是公认的不良预后因素。血管浸润在历史上是通过苏木精和伊红染色来识别的，然而这项技术是非特异性的，在区分血管和淋巴管方面效果不佳。使用免疫组织化学的新技术能够更敏感、更特异地识别淋巴管浸润，并且能够准确区分淋巴管和血管。本综述将讨论目前可用于评估淋巴管浸润的方法。此外，它将聚焦于淋巴管浸润在乳腺癌和黑色素瘤中的作用，探讨每种肿瘤类型中淋巴管浸润和血管浸润的相对重要性。
