乳腺癌中的杂合性缺失：原因还是结果？ - Suppr | 超能文献

Loss of heterozygosity in breast cancer: cause or effect?

作者信息

McGuire W L, Naylor S L

出版信息

J Natl Cancer Inst. 1989 Dec 6;81(23):1764-5. doi: 10.1093/jnci/81.23.1764.

DOI:10.1093/jnci/81.23.1764

Abstract

摘要

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Loss of heterozygosity in breast cancer: cause or effect?乳腺癌中的杂合性缺失：原因还是结果？

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Allelic loss on a chromosome 17 in ductal carcinoma in situ of the breast.乳腺导管原位癌中17号染色体上的等位基因缺失。

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Different tumor types from BRCA2 carriers show wild-type chromosome deletions on 13q12-q13.携带BRCA2基因的不同肿瘤类型在13q12 - q13区域显示野生型染色体缺失。

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Presence of two members of c-erbA receptor gene family (c-erbA beta and c-erbA2) in smallest region of somatic homozygosity on chromosome 3p21-p25 in human breast carcinoma.在人类乳腺癌3号染色体p21 - p25区域的体细胞纯合最小区域中存在c - erbA受体基因家族的两个成员（c - erbAβ和c - erbA2）。

J Natl Cancer Inst. 1989 Dec 6;81(23):1815-20. doi: 10.1093/jnci/81.23.1815.

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Loss of heterozygosity on chromosomes 17 and 18 in breast carcinoma: two additional regions identified.乳腺癌中17号和18号染色体杂合性缺失：另外两个区域被确定。

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Detailed deletion mapping of chromosome arm 3p in breast cancers: a 2-cM region on 3p14.3-21.1 and a 5-cM region on 3p24.3-25.1 commonly deleted in tumors.乳腺癌中3号染色体短臂的详细缺失图谱：3p14.3 - 21.1区域的一个2厘摩区域和3p24.3 - 25.1区域的一个5厘摩区域在肿瘤中常见缺失。

Genes Chromosomes Cancer. 1997 Nov;20(3):268-74.

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Technical approach for the study of the genetic evolution of breast cancer from paraffin-embedded tissue sections.

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