Schaumann B A, Winge V B, Pederson M
Research Service, Veterans Administration Medical Center, Portland, OR 97207.
J Toxicol Environ Health. 1989;28(3):277-84. doi: 10.1080/15287398909531348.
The potential of phenobarbital to interact with DNA has been studied using the sister chromatid exchange (SCE) assay in peripheral lymphocytes of nine adult male patients with epilepsy and of their matched controls. All patients were otherwise healthy individuals, treated chronically with phenobarbital in monotherapy. No statistically significant differences in SCE levels were found between the patient and control groups. Smoking was associated with increased SCE frequencies. The experiment was repeated with five available patients, using a slightly modified methodology. Although different SCE scores were obtained, the results of both tests were comparable.
已使用姐妹染色单体交换（SCE）试验，对9名成年男性癫痫患者及其配对对照的外周淋巴细胞进行研究，以探讨苯巴比妥与DNA相互作用的可能性。所有患者在其他方面均为健康个体，接受苯巴比妥单药长期治疗。患者组和对照组之间的SCE水平未发现统计学上的显著差异。吸烟与SCE频率增加有关。使用略有修改的方法，对5名可用患者重复了该实验。尽管获得了不同的SCE分数，但两次测试的结果具有可比性。
