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Neuroscience: Binge drinking and brain stress systems.

作者信息

O'Connor Richard M, Kenny Paul J

机构信息

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.

出版信息

Nature. 2015 Apr 9;520(7546):168-9. doi: 10.1038/520168a.

DOI:10.1038/520168a
PMID:25855451
Abstract
摘要

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Neuroscience: Binge drinking and brain stress systems.神经科学:暴饮与大脑应激系统
Nature. 2015 Apr 9;520(7546):168-9. doi: 10.1038/520168a.
2
NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking.神经肽Y信号传导抑制终纹床核扩展杏仁核促肾上腺皮质激素释放因子神经元,以抑制暴饮酒精行为。
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Neuropeptide Y Y1 receptor-mediated anxiolysis in the dorsocaudal lateral septum: functional antagonism of corticotropin-releasing hormone-induced anxiety.神经肽Y Y1受体介导的背尾侧外侧隔区抗焦虑作用:促肾上腺皮质激素释放激素诱导焦虑的功能拮抗
Neuroscience. 2001;104(3):799-806. doi: 10.1016/s0306-4522(01)00116-6.
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Medial prefrontal cortex neuropeptide Y modulates binge-like ethanol consumption in C57BL/6J mice.内侧前额叶皮层神经肽 Y 调节 C57BL/6J 小鼠 binge 样乙醇消费。
Neuropsychopharmacology. 2019 May;44(6):1132-1140. doi: 10.1038/s41386-018-0310-7. Epub 2019 Jan 7.
5
Locus coeruleus response to single-prolonged stress and early intervention with intranasal neuropeptide Y.蓝斑对单次长时间应激的反应及鼻内注射神经肽Y的早期干预
J Neurochem. 2015 Dec;135(5):975-86. doi: 10.1111/jnc.13347. Epub 2015 Sep 30.
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Interactions between NPY and CRF in the amygdala to regulate emotionality.杏仁核中神经肽Y(NPY)与促肾上腺皮质激素释放因子(CRF)之间的相互作用以调节情绪。
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Binge Drinking Decreases Corticotropin-Releasing Factor-Binding Protein Expression in the Medial Prefrontal Cortex of Mice.暴饮会降低小鼠内侧前额叶皮质中促肾上腺皮质激素释放因子结合蛋白的表达。
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Corticotropin-releasing hormone (CRH) mRNA expression in rat central amygdala in cannabinoid tolerance and withdrawal: evidence for an allostatic shift?大麻素耐受和戒断时大鼠中央杏仁核中促肾上腺皮质激素释放激素(CRH)mRNA的表达:适应性负荷转移的证据?
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A single alcohol binge impacts on neutrophil function without changes in gut barrier function and gut microbiome composition in healthy volunteers.单次酗酒会影响健康志愿者中性粒细胞的功能,而不会改变肠道屏障功能和肠道微生物组的组成。
PLoS One. 2019 Feb 1;14(2):e0211703. doi: 10.1371/journal.pone.0211703. eCollection 2019.
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Heavy Drinking in College Students Is Associated with Accelerated Gray Matter Volumetric Decline over a 2 Year Period.大学生酗酒与两年内灰质体积加速下降有关。
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本文引用的文献

1
NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking.神经肽Y信号传导抑制终纹床核扩展杏仁核促肾上腺皮质激素释放因子神经元,以抑制暴饮酒精行为。
Nat Neurosci. 2015 Apr;18(4):545-52. doi: 10.1038/nn.3972. Epub 2015 Mar 9.
2
Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence.神经肽 Y 拮抗酒精对杏仁核中γ-氨基丁酸释放的影响,并阻止向酒精依赖的转变。
Biol Psychiatry. 2011 Jun 1;69(11):1091-9. doi: 10.1016/j.biopsych.2011.02.004. Epub 2011 Apr 3.
3
Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence.
促肾上腺皮质释放因子诱导的杏仁核γ-氨基丁酸释放在酒精依赖中起关键作用。
Biol Psychiatry. 2010 May 1;67(9):831-9. doi: 10.1016/j.biopsych.2009.11.007. Epub 2010 Jan 8.
4
A key role for corticotropin-releasing factor in alcohol dependence.促肾上腺皮质激素释放因子在酒精依赖中起关键作用。
Trends Neurosci. 2007 Aug;30(8):399-406. doi: 10.1016/j.tins.2007.06.006. Epub 2007 Jul 16.
5
Plasticity of reward neurocircuitry and the 'dark side' of drug addiction.奖赏神经回路的可塑性与药物成瘾的“阴暗面”
Nat Neurosci. 2005 Nov;8(11):1442-4. doi: 10.1038/nn1105-1442.
6
The NPY system in stress, anxiety and depression.应激、焦虑和抑郁中的神经肽Y系统。
Neuropeptides. 2004 Aug;38(4):213-24. doi: 10.1016/j.npep.2004.05.002.
7
Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression.焦虑和抑郁中的促肾上腺皮质激素释放因子受体1和2
Curr Opin Pharmacol. 2002 Feb;2(1):23-33. doi: 10.1016/s1471-4892(01)00117-5.
8
A role for the bed nucleus of the stria terminalis, but not the amygdala, in the effects of corticotropin-releasing factor on stress-induced reinstatement of cocaine seeking.终纹床核而非杏仁核在促肾上腺皮质激素释放因子对应激诱导的可卡因觅求恢复的影响中所起的作用。
J Neurosci. 1999 Oct 15;19(20):RC35. doi: 10.1523/JNEUROSCI.19-20-j0006.1999.
9
The interaction of alcohol and stress. A review.酒精与压力的相互作用。一篇综述。
Neurosci Biobehav Rev. 1981 Summer;5(2):209-29. doi: 10.1016/0149-7634(81)90003-8.