1Center for Individualized Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Clin Pharmacol Ther. 2019 Jan;105(1):42-44. doi: 10.1002/cpt.1274. Epub 2018 Dec 5.
Although pharmacogenomics (PGx) offers the promise of ensuring the right patient receives the right medication at the right dose the first time, gene-drug interaction data have yet to be seamlessly integrated into patients' health records. PGx testing that is preemptive, adaptable, current, and executable (PACE) overcomes the human and technological barriers to successful implementation, thus capitalizing on the affordable cost of such testing and clinical practice guidelines at the point of prescription ordering.
虽然药物基因组学 (PGx) 有望确保合适的患者在第一次服用正确的药物和正确的剂量,但基因-药物相互作用数据尚未无缝整合到患者的健康记录中。具有前瞻性、适应性、及时性和可执行性 (PACE) 的 PGx 检测克服了成功实施的人为和技术障碍,从而利用了这种检测和临床实践指南在处方开具点的可承受成本。