Dickinson Jasmine R, Scherrer Grégory
Department of Anesthesiology, Perioperative and Pain Medicine, Department of Molecular and Cellular Physiology, Department of Neurosurgery, Stanford Neurosciences Institute, Stanford University, Palo Alto, CA 94304, USA; Biology Graduate Program, Stanford University, Stanford, CA 94305, USA.
Department of Anesthesiology, Perioperative and Pain Medicine, Department of Molecular and Cellular Physiology, Department of Neurosurgery, Stanford Neurosciences Institute, Stanford University, Palo Alto, CA 94304, USA.
Neuron. 2015 Apr 8;86(1):4-6. doi: 10.1016/j.neuron.2015.03.045.
In this issue of Neuron, Santello and Nevian (2015) report HCN channel plasticity and increased temporal summation in layer 5 ACC neurons following nerve injury. They are able to restore HCN channel function and reduce behavioral hypersensitivity with selective serotonin receptor targeting.
在本期《神经元》杂志中，桑泰洛和内维安（2015年）报告了神经损伤后5层前扣带回皮质（ACC）神经元中HCN通道可塑性及时间总和增加的情况。他们通过靶向选择性5-羟色胺受体，能够恢复HCN通道功能并减轻行为超敏反应。
