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无症状心肌缺血监测在预测接受外周血管手术患者围手术期心肌梗死中的价值。

The value of silent myocardial ischemia monitoring in the prediction of perioperative myocardial infarction in patients undergoing peripheral vascular surgery.

作者信息

Pasternack P F, Grossi E A, Baumann F G, Riles T S, Lamparello P J, Giangola G, Primis L K, Mintzer R, Imparato A M

机构信息

Department of Medicine, New York University Medical Center, NY 10016.

出版信息

J Vasc Surg. 1989 Dec;10(6):617-25. doi: 10.1067/mva.1989.15572.

Abstract

Real-time electrocardiographic monitoring for silent myocardial ischemia was performed on 200 patients undergoing peripheral vascular surgery to try to better define those at high risk of perioperative myocardial infarction. The patients were divided into those undergoing abdominal aortic aneurysm or lower extremity revascularization procedures (group I, n = 120) and those undergoing carotid artery endarterectomy (group II, n = 80). Silent ischemia was detected during the preoperative, intraoperative, or post-operative periods in 60.8% of group I and 67.5% of group II patients. Six group I and three group II patients suffered an acute perioperative myocardial infarction with two cardiac deaths. In both groups I and II a variety of parameters based on monitoring of silent myocardial ischemia were compared between the subgroups of patients who had myocardial infarction and those who did not. The results show that in both groups there was a significantly (p less than or equal to 0.05) greater total duration of perioperative ischemic time, total number of perioperative ischemic episodes, and total duration of perioperative ischemic time as a percent of total monitoring time in patients who suffered a perioperative myocardial infarction compared to those who did not. Multivariate logistic regression analysis of preoperative characteristics in all 200 patients showed the occurrence of preoperative silent myocardial ischemia and angina at rest to be the only significant predictors of perioperative myocardial infarction. Thus perioperative monitoring for silent myocardial ischemia might noninvasively identify those patients undergoing peripheral vascular surgery who are at increased risk for perioperative myocardial infarction, permitting implementation of timely preventive measures in selected patients.

摘要

对200例接受外周血管手术的患者进行实时心电图监测以检测无症状心肌缺血,试图更好地界定围手术期心肌梗死高危患者。患者被分为接受腹主动脉瘤或下肢血管重建手术的患者(I组,n = 120)和接受颈动脉内膜切除术的患者(II组,n = 80)。I组60.8%的患者和II组67.5%的患者在术前、术中或术后检测到无症状缺血。I组6例患者和II组3例患者发生围手术期急性心肌梗死,2例患者死于心脏疾病。在I组和II组中,对发生心肌梗死和未发生心肌梗死的患者亚组,比较了基于无症状心肌缺血监测的各种参数。结果显示,与未发生围手术期心肌梗死的患者相比,发生围手术期心肌梗死的患者在围手术期缺血总时长、围手术期缺血发作总数以及围手术期缺血总时长占总监测时长的百分比方面均显著更高(p≤0.05)。对所有200例患者术前特征进行多因素逻辑回归分析显示,术前无症状心肌缺血和静息性心绞痛的发生是围手术期心肌梗死唯一显著的预测因素。因此,围手术期无症状心肌缺血监测可能会无创地识别出接受外周血管手术且围手术期心肌梗死风险增加的患者,从而允许对选定患者实施及时的预防措施。

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