Bellassoued Khaled, Ghrab Ferdaws, Makni-Ayadi Fatma, Van Pelt Jos, Elfeki Abdelfattah, Ammar Emna
Animal Ecophysiology Laboratory, Department of Life Sciences, Sciences Faculty of Sfax, University of Sfax , Sfax , Tunisia .
Pharm Biol. 2015;53(11):1699-709. doi: 10.3109/13880209.2014.1001408. Epub 2015 Apr 9.
Kombucha (KT) is claimed to have various beneficial effects on human health, but there is very little scientific evidence available in the literature.
The present study investigates the effects of Camellia sinensis (GT) Linn. (Theaceae) and KT, two natural drinks, on cholesterol and antioxidant status using a hypercholesterolemia rat model.
The present study compared the free-radical scavenging abilities and polyphenol levels of GT and KT. Wistar rats fed cholesterol-rich diets were given KT or GT (5 mL/kg body weight per day, po) for 16 weeks, then fasted overnight and sacrificed. The plasma lipid levels, thiobarbituric acid reactive substances (TBARS) and aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl transpeptidase (GGT) serum levels, antioxidant activities of superoxide dismutase (SOD) and catalase (CAT), and creatinine and urea rats were examined.
KT had a phenolic compound of 955 ± 0.75 mg GAE/g) followed, by GT (788.92 ± 0.02 mg GAE/g). The free radical scavenging activity of KT was higher than GT. Compared with GT, KT induced lowered serum levels of TC, TG, VLDL-C, and LDL-C by 26, 27, 28, and 36%, respectively, and increased the serum level of high-density lipoprotein cholesterol (HDL-C). KT induced a 55% decrease of TBARS level in liver and 44% in kidney, compared with those of rats fed a cholesterol-rich diet alone. Moreover, CAT and SOD activities were reduced by 29 and 33%, respectively, in liver and 31 and 35%, respectively, in kidney, after oral administration of KT, compared with those of HCD-fed rats.
The findings revealed that KT administration induced attractive curative effects on hypercholesterolemic, particularly in terms of liver-kidney functions in rats. Its effect on humans needs to be studied further.
康普茶（KT）据称对人体健康有多种有益作用，但文献中几乎没有科学证据。
本研究使用高胆固醇血症大鼠模型，研究两种天然饮品——茶树（GT） Linn.（山茶科）和康普茶（KT）对胆固醇及抗氧化状态的影响。
本研究比较了GT和KT的自由基清除能力及多酚含量。给喂食富含胆固醇饮食的Wistar大鼠每日经口给予KT或GT（5毫升/千克体重），持续16周，然后禁食过夜并处死。检测血浆脂质水平、硫代巴比妥酸反应性物质（TBARS）以及天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）和γ-谷氨酰转肽酶（GGT）的血清水平、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的抗氧化活性，以及大鼠的肌酐和尿素水平。
KT的酚类化合物含量为955±0.75毫克没食子酸当量/克，其次是GT（788.92±0.02毫克没食子酸当量/克）。KT的自由基清除活性高于GT。与GT相比，KT使血清总胆固醇（TC）、甘油三酯（TG）、极低密度脂蛋白胆固醇（VLDL-C）和低密度脂蛋白胆固醇（LDL-C）水平分别降低了26%、27%、28%和36%，并提高了血清高密度脂蛋白胆固醇（HDL-C）水平。与仅喂食富含胆固醇饮食的大鼠相比，KT使肝脏中TBARS水平降低了55%，肾脏中降低了44%。此外，口服KT后，与喂食高胆固醇饮食（HCD）的大鼠相比，肝脏中CAT和SOD活性分别降低了29%和33%，肾脏中分别降低了31%和35%。
研究结果表明，给予KT对高胆固醇血症具有显著疗效，尤其是对大鼠的肝肾功方面。其对人类的影响有待进一步研究。
