Center for Immunity and Inflammation, New Jersey Medical School, Rutgers University, Newark, NJ 07103, USA.
Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.
Cell Host Microbe. 2015 Apr 8;17(4):421-3. doi: 10.1016/j.chom.2015.03.012.
Vaccines are needed to combat the global rise in fungal diseases. In this issue of Cell Host & Microbe, Wüthrich et al. (2015) identify calnexin as a target of antigen-specific CD4 T cell responses against multiple fungal pathogens. This study illustrates that a conserved epitope triggers convergent cell-mediated immune responses to confer heterologous antifungal immunity.
疫苗对于应对全球真菌病的上升是必要的。在本期《细胞宿主与微生物》中，Wüthrich 等人（2015）确定钙网蛋白是针对多种真菌病原体的抗原特异性 CD4 T 细胞反应的靶标。这项研究表明，一个保守表位引发趋同的细胞介导免疫反应，从而赋予异源抗真菌免疫。
