Yang Jing, Zhong Fei, Qiu Ju, Wang Kai
Department of Neurology, The Affiliated Anhui Provincial Hospital, Anhui Medical University, Hefei, China.
Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Asia Pac J Clin Oncol. 2015 Dec;11(4):277-81. doi: 10.1111/ajco.12347. Epub 2015 Apr 9.
Androgen-deprivation therapy (ADT) is a main treatment option for patients with prostate cancer (PCa), but its effect on cognition remains unclear. The primary purpose of this cross-sectional case-control study was to evaluate the effects of ADT on cognition in Chinese PCa patients.
Participants included PCa patients who had undergone ADT (ADT group, n = 33) and patients who did not undergo ADT (non-ADT group, n = 32), as well as age- and education-matched healthy controls (HC group, n = 35). All participants were examined using the neuropsychological battery aimed at assessing several cognitive domains including attention, memory and information processing performance.
The ADT group obtained significantly worse scores than the non-ADT and HC groups in the following neuropsychological tests: Recognition (P < 0.01), WAIS Digit Span forward (P < 0.05), Trailmaking B (P < 0.01) and Stroop Interference test (P < 0.01). No significant difference was found between the non-ADT and HC groups (P > 0.05).
Chinese PCa patients receiving ADT showed cognitive impairments in several domains including memory, attention and information processing performance.
雄激素剥夺疗法（ADT）是前列腺癌（PCa）患者的主要治疗选择，但其对认知的影响尚不清楚。本横断面病例对照研究的主要目的是评估ADT对中国PCa患者认知的影响。
参与者包括接受ADT的PCa患者（ADT组，n = 33）、未接受ADT的患者（非ADT组，n = 32）以及年龄和教育程度匹配的健康对照者（HC组，n = 35）。所有参与者均使用旨在评估包括注意力、记忆力和信息处理能力在内的多个认知领域的神经心理测试组合进行检查。
在以下神经心理测试中，ADT组的得分显著低于非ADT组和HC组：识别（P < 0.01）、韦氏成人智力量表数字广度顺背（P < 0.05）、连线测验B（P < 0.01）和斯特鲁普干扰测试（P < 0.01）。非ADT组和HC组之间未发现显著差异（P > 0.05）。
接受ADT的中国PCa患者在包括记忆、注意力和信息处理能力在内的多个领域存在认知障碍。
