Sharma Rajeev, Saigal Renu, Goyal Laxmikant, Mital Pradeep, Yadav R N, Meena P D, Agrawal Abhishek
J Assoc Physicians India. 2014 Aug;62(8):678-81.
To detect level of serum vitamin D in patients of Rheumatoid arthritis (RA) and to establish relationship between serum vitamin D level and disease activity in RA.
Eighty patients of RA fulfilling 1987 revised criteria of the American College of Rheumatology (ACR) of RA classification and eighty healthy controls were included in the study. 25 (OH) vitamin D levels were measured. Disease activity was assessed by DAS-28 score.
Ninety percent of RA patients were either vitamin D deficient or insufficient while only seventy percent of healthy controls were either vitamin D deficient or insufficient(p=0.007). Mean serum vitamin D levels of RA patients was significantly low compared to healthy controls (p=0.009). Thirty-one patients had high disease activity (DAS-28 score >5.1, group A), 32 patients had moderate disease activity (DAS 28 score 3.2-5.1, group B) and 17 patients had low disease activity (DAS-28 score <3.2, group C). Vitamin D levels in high disease activity group was significantly low compared to vitamin D level in patients with low and moderate disease activity (p<.001) and vitamin D level had significant negative correlation with DAS28 score (r=-0.604, p<0.001).
Serum vitamin D levels were significantly low in RA patients than in healthy controls. Vitamin D deficiency was seen in significantly higher numbers of patients and vitamin D had negative correlation with disease activity in RA.
检测类风湿关节炎（RA）患者血清维生素D水平，并建立血清维生素D水平与RA疾病活动度之间的关系。
本研究纳入了80例符合1987年美国风湿病学会（ACR）修订的RA分类标准的RA患者和80例健康对照。检测25（OH）维生素D水平。采用DAS-28评分评估疾病活动度。
90%的RA患者存在维生素D缺乏或不足，而健康对照中只有70%存在维生素D缺乏或不足（p=0.007）。与健康对照相比，RA患者的血清维生素D平均水平显著降低（p=0.009）。31例患者疾病活动度高（DAS-28评分>5.1，A组），32例患者疾病活动度中等（DAS 28评分3.2-5.1，B组），17例患者疾病活动度低（DAS-28评分<3.2，C组）。疾病活动度高的组的维生素D水平与疾病活动度低和中等的患者相比显著降低（p<0.001），且维生素D水平与DAS28评分呈显著负相关（r=-0.604，p<0.001）。
RA患者血清维生素D水平显著低于健康对照。RA患者中维生素D缺乏的人数显著更多，且维生素D与RA疾病活动度呈负相关。
