Mustafa Mohamed Mohamed Elfaith, Imad Taha Ziryab, Hamza Salih Boushra, Abdalla Yassin A, Noor Sufian K, William Jimmy
Rheumatology Speciality Department, Sudan Medical Specialization Board, Khartoum, Sudan.
Department of Internal Medicine, Faculty of Medicine and Health Sciences, Omdurman Islamic University, Khartoum, Sudan.
Open Access Rheumatol. 2023 Sep 20;15:181-187. doi: 10.2147/OARRR.S425397. eCollection 2023.
To evaluate vitamin D levels among adult Sudanese RA patients and identify its correlation with RA disease activity.
A bicentric cross-sectional analytical hospital-based study was performed in two Khartoum State Hospitals between October 2019 and January 2020, enrolling 90 Sudanese patients with RA. Serum vitamin D levels were measured with a standard reference level of 30ng/mL-100ng/mL. A detailed interview-based questionnaire was used to collect the patient's information, clinical data and lab results-disease activity was assessed via the DAS-28 score. The data was then analyzed using SPSS v-24.
Vitamin D levels were low in 79 candidates (87.8%), 53 of which (67.1%) showed moderate insufficiency (10-30ng/mL), and 26 candidates (32.9%) had severe deficiency (less than 10 ng/mL). Regarding the disease activity, 57 participants (63.3%) had moderate disease activity (DAS-28=3.2-5.1), and 22 participants (24.4%) had high disease activity (DAS-28 >5.1). A significant negative correlation was reported between high DAS-28 scores and low vitamin D levels with p-value = <0.001 (95% CI: -0.8591 to 0.0015) and r = -0.44.
Most adult Sudanese rheumatoid arthritis patients showed low vitamin D levels (87.8%), which was also significantly correlated with increased disease activity (P-value <0.05). Moreover, the prevalence of low vitamin D levels was significantly higher than in numerous countries worldwide.
评估成年苏丹类风湿关节炎（RA）患者的维生素D水平，并确定其与RA疾病活动度的相关性。
2019年10月至2020年1月期间，在喀土穆州的两家医院进行了一项以医院为基础的双中心横断面分析研究，纳入了90例苏丹RA患者。采用标准参考水平为30ng/mL - 100ng/mL来测量血清维生素D水平。通过基于详细访谈的问卷收集患者信息、临床数据和实验室结果，通过DAS - 28评分评估疾病活动度。然后使用SPSS v - 24对数据进行分析。
79名受试者（87.8%）维生素D水平较低，其中53名（67.1%）表现为中度不足（10 - 30ng/mL），26名受试者（32.9%）存在严重缺乏（低于10ng/mL）。关于疾病活动度，57名参与者（63.3%）具有中度疾病活动度（DAS - 28 = 3.2 - 5.1），22名参与者（24.4%）具有高度疾病活动度（DAS - 28 > 5.1）。高DAS - 28评分与低维生素D水平之间存在显著负相关，p值 = <0.001（95%CI： - 0.8591至0.0015），r = - 0.44。
大多数成年苏丹类风湿关节炎患者维生素D水平较低（87.8%），这也与疾病活动度增加显著相关（P值 < 0.05）。此外，低维生素D水平的患病率明显高于世界上许多国家。
