Kaneko T
Masui. 1989 Nov;38(11):1411-20.
We studied the effect of intratracheally infused bile acids on the respiratory and circulatory systems in anesthetized dogs. The bile acids used were cholic acid, deoxycholic acid, taurocholic acid, glycocholic acid and taurodeoxycholic acid. They were diluted to 1% or 10% with normal saline solution and 1 ml.kg-1 was infused into the trachea through an endotracheal tube under a controlled ventilation with air. Injection of 10% diluted bile acid, except for glycocholic acid, decreased PaO2 to less than 50 torr after 15 minutes and increased PaCO2 to above 60 torr after 2 hours. A butterfly shadow appeared in chest radiographs after 1 hour. Microscopic examinations revealed severe pulmonary edema and hemorrhage but circulatory depression was negligible. Hypoxia and hypercapnea were also observed in the 1% dilution group but to a smaller degree. Intrapulmonary water volume increased following injection of bile acid. Our results demonstrated that bile acids induce pulmonary damage.
我们研究了经气管内注入胆汁酸对麻醉犬呼吸和循环系统的影响。所用的胆汁酸为胆酸、脱氧胆酸、牛磺胆酸、甘胆酸和牛磺脱氧胆酸。将它们用生理盐水稀释至1%或10%，在空气控制通气下，通过气管内导管以1 ml.kg-1的剂量注入气管。注入10%稀释胆汁酸（甘胆酸除外）后，15分钟内动脉血氧分压（PaO2）降至50托以下，2小时后动脉血二氧化碳分压（PaCO2）升至60托以上。1小时后胸部X光片出现蝶形阴影。显微镜检查显示有严重的肺水肿和出血，但循环抑制可忽略不计。1%稀释组也观察到低氧血症和高碳酸血症，但程度较轻。注入胆汁酸后肺内水量增加。我们的结果表明胆汁酸可导致肺损伤。
