Kaneko T, Sato T, Katsuya H, Miyauchi Y
First Department of Surgery, Kumamoto University Medical School, Japan.
Crit Care Med. 1990 Jan;18(1):77-83. doi: 10.1097/00003246-199001000-00017.
Intratracheally injected bile acid has been shown to produce severe pulmonary edema. We investigated the therapeutic effect of an exogenous surfactant for aspirated bile acid. Anesthetized rabbits were injected intratracheally with 1 ml/kg body weight of taurocholic acid, diluted to 0.6% with normal saline solution. After the injection of taurocholic acid, the PaO2 values decreased, the PaCO2 values increased, and abnormal shadows appeared in chest x-rays. After surfactant injection, the rabbits improved, but pulmonary edema recurred after one hour. After additional injection of the surfactant, the improved condition was sustained for 6 h. All animals in the untreated group died within 5 h and were shown to have severe pulmonary edema. Conversely, microscopic examination revealed no pulmonary edema in animals surviving 6 h after surfactant treatment. Thus, exogenous surfactant can prevent damage to the lung caused by intratracheally injected bile acid.
经气管内注射胆汁酸已被证明会导致严重的肺水肿。我们研究了外源性表面活性剂对吸入胆汁酸的治疗效果。将麻醉的兔子经气管内注射1毫升/千克体重的牛磺胆酸，用生理盐水稀释至0.6%。注射牛磺胆酸后，动脉血氧分压（PaO2）值下降，动脉血二氧化碳分压（PaCO2）值上升，胸部X光片出现异常阴影。注射表面活性剂后，兔子情况有所改善，但1小时后肺水肿复发。再次注射表面活性剂后，改善状况持续了6小时。未治疗组的所有动物在5小时内死亡，且显示有严重的肺水肿。相反，显微镜检查显示，表面活性剂治疗后存活6小时的动物没有肺水肿。因此，外源性表面活性剂可以预防经气管内注射胆汁酸对肺部造成的损害。
