Borkoles Erika, Reynolds Nick, Thompson David R, Ski Chantal F, Stojanovska Lily, Polman Remco C J
Institute of Sport, Exercise and Active Living, Victoria University, Melbourne, Australia.
Institute of Sport, Exercise and Active Living, Victoria University, Melbourne, Australia; Centre for the Heart and Mind, Australian Catholic University, Melbourne, Australia.
Maturitas. 2015 Jun;81(2):306-10. doi: 10.1016/j.maturitas.2015.03.007. Epub 2015 Mar 18.
There is evidence that menopausal symptoms manifested at peri-menopause occur less frequently when compared to the symptoms experienced at post-menopause. The aim of this study was to investigate this and to test the hypothesis that depressive symptomatology mediates the relationship between menopausal stage and symptom frequency.
This cross-sectional study included 213 women (M age=52 years), of whom 125 were peri- and 88 post-menopausal. Measures comprised the Center for Epidemiologic Studies-Depression scale (CES-D) and the Women's Health Questionnaire (WHQ) vasomotor symptoms and somatic symptoms subscales.
Multiple mediated regression analyses provided evidence that somatic symptoms and vasomotor symptoms were less frequent at post- compared to peri-menopause, and that these differences were mediated by depressive symptomatology. Multivariate effect sizes ranged from small to moderate, and univariate effect sizes were uniformly small with wide confidence intervals.
The frequency of vasomotor and somatic symptoms appears to increase with depressed affect. The management of symptoms could include interventions of a psychotherapeutic nature, which may offset this effect, particularly in women for whom depressive symptoms are a feature of the climacteric syndrome. The extent to which depression and the climacteric syndrome may be causally related to one another remains unclear and longitudinal research should further examine the mechanisms of this association.
有证据表明，与绝经后期出现的症状相比，围绝经期出现的绝经症状频率较低。本研究的目的是对此进行调查，并检验抑郁症状介导绝经阶段与症状频率之间关系的假设。
这项横断面研究纳入了213名女性（平均年龄 = 52岁），其中125名为围绝经期女性，88名为绝经后期女性。测量指标包括流行病学研究中心抑郁量表（CES-D）以及女性健康问卷（WHQ）中的血管舒缩症状和躯体症状分量表。
多重中介回归分析表明，与围绝经期相比，绝经后期的躯体症状和血管舒缩症状频率较低，且这些差异由抑郁症状介导。多变量效应大小范围从小到中等，单变量效应大小均较小，置信区间较宽。
血管舒缩症状和躯体症状的频率似乎随着情绪低落而增加。症状管理可包括心理治疗性质的干预措施，这可能会抵消这种影响，尤其是对于那些以抑郁症状为更年期综合征特征的女性。抑郁与更年期综合征之间因果关系的程度尚不清楚，纵向研究应进一步探究这种关联的机制。
