Wu Ying-Ying, Xiao E, Graves Dana T
1] State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China [2] School of Dental Medicine, University of Pennsylvania, Philadelphia, USA.
1] School of Dental Medicine, University of Pennsylvania, Philadelphia, USA [2] Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.
Int J Oral Sci. 2015 Jun 26;7(2):63-72. doi: 10.1038/ijos.2015.2.
Diabetes mellitus and periodontal disease are chronic diseases affecting a large number of populations worldwide. Changed bone metabolism is one of the important long-term complications associated with diabetes mellitus. Alveolar bone loss is one of the main outcomes of periodontitis, and diabetes is among the primary risk factors for periodontal disease. In this review, we summarise the adverse effects of diabetes on the periodontium in periodontitis subjects, focusing on alveolar bone loss. Bone remodelling begins with osteoclasts resorbing bone, followed by new bone formation by osteoblasts in the resorption lacunae. Therefore, we discuss the potential mechanism of diabetes-enhanced bone loss in relation to osteoblasts and osteoclasts.
糖尿病和牙周病是影响全球大量人群的慢性疾病。骨代谢改变是与糖尿病相关的重要长期并发症之一。牙槽骨丧失是牙周炎的主要后果之一，而糖尿病是牙周病的主要危险因素之一。在本综述中，我们总结了糖尿病对牙周炎患者牙周组织的不良影响，重点关注牙槽骨丧失。骨重塑始于破骨细胞吸收骨，随后成骨细胞在吸收腔隙中形成新骨。因此，我们讨论了糖尿病导致骨丧失增加与成骨细胞和破骨细胞相关的潜在机制。
