Sezai Y, Nagashima T
Nihon Hifuka Gakkai Zasshi. 1989 Jun;99(7):811-7.
The laboratory data from 136 patients suffering from a mass outbreak of rubella were serially examined. Alteration of thrombocytopenia (38.7%), leukopenia (26.4%), increased LDH (94.3%), and increased GOT (32.4%) were observed during the early days of disease. Slightly later, increased GPT was noted in 48.5%. LDH isozymes may be grouped into two specific patterns: 1) an LDH3 dominant pattern appeared (90.4%) during the beginning days of the disease. 2) an LDH3 dominant pattern with LDH5 greater than LDH4 was detected one week later. It was concluded that the increase of LDH3 may have been induced by thrombocytopenia due to viral infection. The increase of LDH5 appears to result from liver damage. In conclusion, LDH isozyme findings are significant in the early diagnosis of liver damage in rubella.
对136例风疹群发患者的实验室数据进行了连续检查。在疾病早期观察到血小板减少（38.7%）、白细胞减少（26.4%）、乳酸脱氢酶升高（94.3%）和谷草转氨酶升高（32.4%）。稍晚些时候，48.5%的患者谷丙转氨酶升高。乳酸脱氢酶同工酶可分为两种特定模式：1）在疾病开始时出现乳酸脱氢酶3为主的模式（90.4%）。2）一周后检测到乳酸脱氢酶5大于乳酸脱氢酶4的乳酸脱氢酶3为主的模式。得出结论，乳酸脱氢酶3的升高可能是由病毒感染引起的血小板减少所致。乳酸脱氢酶5的升高似乎是肝损伤的结果。总之，乳酸脱氢酶同工酶的检测结果对风疹肝损伤的早期诊断具有重要意义。
