Butzelaar Lisolette, Soykan Ezgi A, Galindo Garre Francisca, Beelen Robert H J, Ulrich Magda M, Niessen Frank B, Mink van der Molen Aebele B
Department of Plastic-, Reconstructive- and Hand Surgery, VU University Medical Center, Amsterdam, the Netherlands.
Department of Epidemiology and Biostatistics, University Medical Center, Amsterdam, the Netherlands.
Wound Repair Regen. 2015 Jul-Aug;23(4):531-7. doi: 10.1111/wrr.12302. Epub 2015 Jun 24.
The aim of this study was to examine the association between possible risk factors for excessive scarring and the formation of hypertrophic scars (HTS). Hypertrophic skin scarring remains a difficult problem in medicine and can cause considerable morbidity. Nevertheless, few extensive prospective studies have been conducted which assess risk factors in relation to HTS formation. Therefore, a prospective observational study was performed. Patients who had elective cardiothoracic surgery were followed for the duration of 1 year and information was collected about a variety of possible risk factors in these patients. The associations between the risk factors and the development of HTSs were investigated. Body mass index, ethnic background, and scar related factors are positively associated with HTS formation. Antihypertensive therapeutics and factors influencing erythropoiesis are negatively associated with HTS formation.
本研究的目的是探讨过度瘢痕形成的可能危险因素与增生性瘢痕（HTS）形成之间的关联。增生性皮肤瘢痕在医学上仍然是一个难题，会导致相当大的发病率。然而，很少有广泛的前瞻性研究评估与HTS形成相关的危险因素。因此，进行了一项前瞻性观察性研究。对接受择期心胸外科手术的患者进行了为期1年的随访，并收集了这些患者各种可能危险因素的信息。研究了危险因素与HTS发生之间的关联。体重指数、种族背景和瘢痕相关因素与HTS形成呈正相关。抗高血压治疗药物和影响红细胞生成的因素与HTS形成呈负相关。
