Asahina A, Matsuyama T, Tsuchida T, Nakagawa H, Seki T, Otsuka F, Ishibashi Y
Nihon Hifuka Gakkai Zasshi. 1989 Jul;99(8):899-906.
Two cases of subungual pigmented nevi with periungual melanotic freckles, namely Hutchinson's sign, are presented. They are a 4-year-old female and a 11-month-old male; in neither case did the mother notice the lesion at birth. Histologically, both cases were characterized by the presence of well-circumscribed small nests of nevus cells in the periungual melanotic areas; diagnoses of junctional nevus and compound nevus were made, respectively. However, atypical proliferations of melanocytes at the dermo-epidermal junction of the nail matrix and nail bed were observed in some areas. The measurement of the DNA content of melanocytes by means of microfluorometry revealed normal diploid pattern in the former case, but the latter case contained a few aneuploid cells, suggesting that the proliferating melanocytes might have malignant potentials. Infantile subungual pigmented nevi with Hutchinson's sign must be examined thoroughly and watched carefully.
本文报告两例伴有甲周黑素雀斑（即哈钦森征）的甲下色素痣。患者分别为一名4岁女性和一名11个月大的男性；两例患者的母亲在患儿出生时均未注意到病变。组织学上，两例病例的特征均为甲周黑素区域存在边界清晰的小巢状痣细胞；分别诊断为交界痣和复合痣。然而，在某些区域观察到甲母质和甲床的真皮 - 表皮交界处黑素细胞有非典型增生。通过显微荧光测定法测量黑素细胞的DNA含量，结果显示前一例为正常二倍体模式，但后一例含有一些非整倍体细胞，提示增殖的黑素细胞可能具有恶性潜能。伴有哈钦森征的婴儿甲下色素痣必须进行全面检查并密切观察。
