Asahina A, Chi H I, Otsuka F
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
J Dermatol. 1993 Aug;20(8):466-72. doi: 10.1111/j.1346-8138.1993.tb01322.x.
The discrimination between subungual pigmented nevus and subungual melanoma in situ is still a clinical problem. We measured DNA ploidy in six cases of subungual melanotic lesions which exhibited the features of subungual pigmented nevus or lentigo simplex histologically. Five cases presented a diploid pattern with or without a slight increase of hyperdiploid cells. One case presented a polyploid pattern; it also exhibited histologically abnormal melanocytes with large nuclei and pigment-filled elongated dendrites. The DNA ploidy pattern and histologic features suggest that the lesion of this latter case contains abnormal melanocytes which probably have the potential to undergo a malignant transformation into a subungual melanoma. DNA ploidy analysis, therefore, is likely to provide information for evaluating the biologic behavior of subungual melanotic lesions.
甲下色素痣与原位甲下黑色素瘤的鉴别仍是一个临床问题。我们对6例甲下黑色素病变进行了DNA倍体测量，这些病变在组织学上表现出甲下色素痣或单纯性雀斑样痣的特征。5例呈现二倍体模式，有或没有超二倍体细胞的轻微增加。1例呈现多倍体模式；其在组织学上也表现为黑素细胞异常，细胞核大，有充满色素的细长树突。DNA倍体模式和组织学特征表明，后一例病变中的黑素细胞异常，可能有恶变转化为甲下黑色素瘤的潜力。因此，DNA倍体分析可能为评估甲下黑色素病变的生物学行为提供信息。
