Yamada Minoru, Nishiguchi Shu, Fukutani Naoto, Aoyama Tomoki, Arai Hidenori
Department of Lifespan Development Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tokyo, Japan.
Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
J Am Med Dir Assoc. 2015 Aug 1;16(8):654-60. doi: 10.1016/j.jamda.2015.02.017. Epub 2015 Apr 7.
The aim of the Intervention by Nutrition and Exercise (INE) study was to investigate the effects of a mail-based intervention for sarcopenia prevention on muscle mass and anabolic hormones in community-dwelling older adults.
A cluster-randomized controlled trial.
This trial recruited community-dwelling adults aged 65 years and older in Japan. The 227 participants were cluster randomized into a walking and nutrition (W/N) group (n = 79), a walking (W) group (n = 71), and a control (C) group (n = 77). We analyzed the physical and biochemical measurements in this substudy.
Six months of mail-based intervention (a pedometer-based walking program and nutritional supplementation).
The skeletal muscle mass index (SMI) using the bioelectrical impedance data acquisition system, biochemical measurements, such as those of insulinlike growth factor (IGF-1), dehydroepiandrosterone sulfate (DHEA-S), and 25-hydroxy vitamin D (25[OH]D), as well as frailty, were assessed by the Cardiovascular Health Study criteria.
Participants in the W/N and W groups had significantly greater improvements in SMI, IGF-1, and 25(OH)D (P < .05) than those in the C group. Participants in the W/N group had significantly greater improvements in DHEA-S (P < .05) than in the other groups. These effects were more pronounced in frail, older adults.
These results suggest that the mail-based walking intervention of the remote monitoring type for sarcopenia prevention can increase anabolic hormone levels and SMI in community-dwelling older adults, particularly in those who are frail.
营养与运动干预（INE）研究的目的是调查一项基于邮件的肌肉减少症预防干预措施对社区居住的老年人肌肉量和合成代谢激素的影响。
一项整群随机对照试验。
该试验招募了日本65岁及以上的社区居住成年人。227名参与者被整群随机分为步行与营养（W/N）组（n = 79）、步行（W）组（n = 71）和对照组（C）组（n = 77）。我们在这项子研究中分析了身体和生化测量结果。
为期6个月的基于邮件的干预（基于计步器的步行计划和营养补充）。
使用生物电阻抗数据采集系统测量骨骼肌质量指数（SMI），进行生化测量，如胰岛素样生长因子（IGF-1）、硫酸脱氢表雄酮（DHEA-S）和25-羟基维生素D（25[OH]D）的测量，并根据心血管健康研究标准评估衰弱情况。
W/N组和W组参与者的SMI、IGF-1和25(OH)D改善程度显著高于C组（P < 0.05）。W/N组参与者的DHEA-S改善程度显著高于其他组（P < 0.05）。这些效果在体弱的老年人中更为明显。
这些结果表明，基于邮件的远程监测型步行干预措施可增加社区居住老年人，尤其是体弱老年人的合成代谢激素水平和SMI，从而预防肌肉减少症。
