Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Curr Treat Options Oncol. 2023 Oct;24(10):1305-1327. doi: 10.1007/s11864-023-01122-y. Epub 2023 Jul 19.
Gastric cancer (GC) is the fifth most common cancer and the third leading cause of cancer death worldwide, which seriously endangers human health. A number of studies have shown that sarcopenia occurs more frequently in patients with gastric cancer than in the general population and can significantly affect the disease status and survival of patients, which is of great significance in predicting the prognosis of gastric cancer. Patients with gastric cancer may suffer sarcopenia no matter before or after surgery, and the pathogenesis is complex. Abnormal nutrient metabolism and reduced exercise are the leading causes. In addition, surgical treatment and chemotherapy for gastric cancer might participate in the physiological and pathological mechanism of sarcopenia. Generally speaking, exercise and nutritional therapy are the main prevention and treatment methods for sarcopenia. But more prospective evidence is needed to establish reasonable interventions, and other drug treatments are in their infancy. For the diagnostic criteria of sarcopenia, the cut-off values of the skeletal muscle mass index obtained from CT images vary widely and need to be standardized and unified. We also need to explore simple predictors to facilitate sarcopenia risk assessment. More research is needed to formulate more appropriate treatments for gastric cancer patients with sarcopenia.
胃癌（GC）是全球第五大常见癌症和第三大癌症死亡原因，严重危害人类健康。许多研究表明，胃癌患者比普通人群更容易发生肌肉减少症，并且可以显著影响患者的疾病状态和生存，这对于预测胃癌的预后具有重要意义。胃癌患者无论在手术前还是手术后都可能患有肌肉减少症，其发病机制复杂。异常的营养代谢和运动量减少是主要原因。此外，胃癌的手术治疗和化疗可能参与肌肉减少症的生理和病理机制。一般来说，运动和营养治疗是肌肉减少症的主要预防和治疗方法。但需要更多的前瞻性证据来建立合理的干预措施，其他药物治疗仍处于起步阶段。对于肌肉减少症的诊断标准，从 CT 图像获得的骨骼肌质量指数的截断值差异很大，需要标准化和统一。我们还需要探索简单的预测因子来方便肌肉减少症风险评估。需要进一步研究为患有肌肉减少症的胃癌患者制定更合适的治疗方法。
