Nath Preethy, Sankey Elizabeth, Murray Elisabeth, Kurup Harish
Pilgrim Hospital, Boston, UK.
BMJ Case Rep. 2015 Apr 9;2015:bcr2014208929. doi: 10.1136/bcr-2014-208929.
We present a case of metastatic adenocarcinoma of the breast in a patient who sustained a pathological fracture of the distal femur. Histology of the distal femur lesion excised at the time of endoprosthetic replacement confirmed this to be a primary chondrosarcoma. We have reviewed the literature and identified previously documented cases of concurrent breast carcinoma and chondrosarcoma of bone. A high index of suspicion is warranted and the diagnosis must be first confirmed before rushing to internal fixation (therapeutic or prophylactic) assuming them to be secondary bone lesions from the known primary cancer even in patients with multiple metastases.
我们报告一例发生股骨远端病理性骨折的乳腺癌转移性腺癌患者。在进行人工关节置换时切除的股骨远端病变组织学检查证实为原发性软骨肉瘤。我们查阅了文献,发现了先前记录的同时存在乳腺癌和骨软骨肉瘤的病例。即使在有多处转移的患者中,对于已知原发性癌症的继发性骨病变,在急于进行内固定(治疗性或预防性)之前,必须高度怀疑并首先确诊。