Hussain Mehwish, Khan Nazeer, Uddin Mudassir, Al-Nozha Mansour M
Department of Statistics, University of Karachi, Karachi, Pakistan ; Department of Research, Dow University of Health Sciences, Karachi, Pakistan.
Department of Research, Jinnah Sindh Medical University, Karachi, Pakistan.
J Cardiovasc Thorac Res. 2015;7(1):6-12. doi: 10.15171/jcvtr.2015.02. Epub 2015 Mar 29.
Coronary artery disease (CAD) is a persistent public health problem worldwide. Chest pain is one of the perceptible symptoms of the same disease. Literature has found acute chest pain as plausible risk factors for CAD. Nevertheless, none of the study has estimated duration from chronic chest pain to the diagnosis of CAD. The objective of the study was to estimate duration from chronic chest pain to CAD and to assess impact of risk factors on same duration.
Data were obtained from community based study on 17,232 Saudi adults. History of patients about onset of chest pain and other risk factors were inquired. Descriptive measures were obtained by Kaplan-Meier curve. Effect of demographic and clinical factors was assessed by Cox regression models.
Out of 24% patients with chest pain, 21% diagnosed with CAD. The average duration was 5 years. About 12% of patients with chest pain diagnosed with CAD after one year. Advancing age, female gender, no exercise and reduced high density lipoprotein (HDL) were significantly hazardous predictors throughout duration from chest pain to diagnosis of CAD.
The duration from chest pain to CAD was 5 years. Age, gender, exercise and HDL can be variables of concern to deteriorate hazards of CAD for patients with chest pain.
冠状动脉疾病（CAD）是全球范围内持续存在的公共卫生问题。胸痛是该疾病的明显症状之一。文献发现急性胸痛是CAD可能的危险因素。然而，尚无研究估计从慢性胸痛到CAD诊断的时间。本研究的目的是估计从慢性胸痛到CAD的时间，并评估危险因素对该时间的影响。
数据来自对17232名沙特成年人的社区研究。询问了患者胸痛发作及其他危险因素的病史。通过Kaplan-Meier曲线获得描述性指标。通过Cox回归模型评估人口统计学和临床因素的影响。
在24%有胸痛的患者中，21%被诊断为CAD。平均时间为5年。约12%有胸痛的患者在1年后被诊断为CAD。从胸痛到CAD诊断的整个过程中，年龄增长、女性、不运动和高密度脂蛋白（HDL）降低是显著的危险因素。
从胸痛到CAD的时间为5年。年龄、性别、运动和HDL可能是影响胸痛患者CAD风险恶化的相关变量。
