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奥沙利铂给药后出现严重急性肾小管坏死。

Severe acute tubular necrosis observed subsequent to oxaliplatin administration.

作者信息

Filewod Niall, Lipman Mark L

机构信息

Department of Medicine , McGill University Health Centre , Montreal, QC , Canada.

Division of Nephrology, Department of Medicine , Jewish General Hospital , Montreal, QC , Canada.

出版信息

Clin Kidney J. 2014 Feb;7(1):68-70. doi: 10.1093/ckj/sft148. Epub 2013 Dec 29.

DOI:10.1093/ckj/sft148
PMID:25859355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4389161/
Abstract

A 67-year-old man known for metastatic colon cancer received treatment with oxaliplatin and developed severe acute kidney injury requiring dialysis. Renal biopsy revealed severe acute tubular necrosis. Acute kidney injury is a rare but severe adverse effect of oxaliplatin administration.

摘要

一名67岁的男性，因转移性结肠癌接受了奥沙利铂治疗，随后出现严重急性肾损伤，需要进行透析。肾活检显示为严重急性肾小管坏死。急性肾损伤是奥沙利铂给药罕见但严重的不良反应。

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本文引用的文献

1
Oxaliplatin-induced acute renal failure presenting clinically as thrombotic microangiopathy: think of acute tubular necrosis.奥沙利铂诱导的急性肾衰竭，临床呈现为血栓性微血管病：应考虑急性肾小管坏死。
NDT Plus. 2009 Jun;2(3):254-6. doi: 10.1093/ndtplus/sfp008. Epub 2009 Feb 4.
2
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Clin Exp Nephrol. 2012 Jun;16(3):490-4. doi: 10.1007/s10157-012-0620-8. Epub 2012 Mar 27.
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Oxaliplatin-induced proximal renal tubular acidosis.
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Acute renal failure related to oxaliplatin-induced intravascular hemolysis.奥沙利铂诱导的血管内溶血导致急性肾衰竭。
Med Oncol. 2010 Dec;27(4):1425-6. doi: 10.1007/s12032-009-9263-3. Epub 2009 Jun 30.
5
Oxaliplatin-induced immune hemolytic anemia: a case report and review of the literature.奥沙利铂诱导的免疫性溶血性贫血：一例报告及文献复习
Anticancer Drugs. 2007 Sep;18(8):973-6. doi: 10.1097/CAD.0b013e3280e9496d.
6
Renal tubular acidosis due to oxaliplatin.奥沙利铂所致肾小管酸中毒
Ann Oncol. 2007 Apr;18(4):805-6. doi: 10.1093/annonc/mdm080.
7
Oxaliplatin-induced hemolytic anemia during adjuvant treatment of a patient with colon cancer: a case report.奥沙利铂在一名结肠癌患者辅助治疗期间引起溶血性贫血：一例病例报告
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8
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Oxaliplatin induces a delayed immune-mediated hemolytic anemia: a case report and review of the literature.
Clin Colorectal Cancer. 2005 Nov;5(4):283-6. doi: 10.3816/ccc.2005.n.041.
10
Renal toxicity of oxaliplatin.奥沙利铂的肾毒性。
Nephrol Dial Transplant. 2005 Jun;20(6):1275-6. doi: 10.1093/ndt/gfh826. Epub 2005 Apr 12.