奥沙利铂引起的局部缺血性坏死。
Digital ischaemia and necrosis from oxaliplatin.
机构信息
Hematology Oncology, University of California San Francisco-Fresno, Fresno, California, USA
Hematology Oncology, University of California San Francisco-Fresno, Clovis, California, USA.
出版信息
BMJ Case Rep. 2022 Feb 7;15(2):e247333. doi: 10.1136/bcr-2021-247333.
Oxaliplatin is a chemotherapeutic agent used in a variety of malignancies such as colorectal cancer and pancreatic cancer. It is a platinum derivative that results in direct cell cytotoxicity with resultant cell death. The most common side effects often noted are neurotoxicity, nausea, vomiting, diarrhoea, hepatotoxicity and myelosuppression. Oxaliplatin induced digital ischaemia and necrosis is a rare side effect that was observed in our patient. In general, digital ischaemia is a rare vascular disorder that is often associated with autoimmune disease. A patient with digital ischaemia due to oxaliplatin will be described in this case report.
奥沙利铂是一种用于多种恶性肿瘤的化疗药物，如结直肠癌和胰腺癌。它是一种铂衍生物，导致直接的细胞细胞毒性，从而导致细胞死亡。最常见的不良反应通常是神经毒性、恶心、呕吐、腹泻、肝毒性和骨髓抑制。奥沙利铂引起的手指缺血性坏死是一种罕见的副作用，在我们的患者中观察到。一般来说，手指缺血性坏死是一种罕见的血管疾病，常与自身免疫性疾病有关。本文将报告 1 例因奥沙利铂导致手指缺血性坏死的患者。
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