Aiwale Amol S, Patel Utkarsh A, Barvaliya Manish J, Jha Pramod R, Tripathi Chandrabhanu
Department of Pharmacology, Government Medical College, Bhavnagar-364001, Gujarat, India.
Curr Drug Saf. 2015;10(1):94-5. doi: 10.2174/1574886309666140930151343.
We report a case of isoniazid induced convulsions in 35 years old male alcoholic and smoker patient receiving intensive phase therapy for pulmonary tuberculosis. A case was confirmed by accidental positive de-challenge and rechallenge as well as ruled out other conditions. Use of isoniazid in alcoholic and smoker patient required a caution for prevention of neurological adverse reactions. Pyridoxine should always be prescribed to such patients for the prevention of such adverse reaction.
我们报告了一例35岁男性酗酒且吸烟的患者，在接受强化期肺结核治疗时出现异烟肼诱发惊厥的病例。该病例经意外的撤药后症状缓解及再用药激发试验得到证实，同时排除了其他疾病。在酗酒且吸烟的患者中使用异烟肼时，需谨慎预防神经不良反应。此类患者应始终开具维生素B6以预防此类不良反应。
