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2
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本文引用的文献

1
Guidelines for the Treatment of Latent Tuberculosis Infection: Recommendations from the National Tuberculosis Controllers Association and CDC, 2020.潜伏结核感染治疗指南：美国国家结核病控制协会和美国疾病预防控制中心 2020 年推荐意见。
MMWR Recomm Rep. 2020 Feb 14;69(1):1-11. doi: 10.15585/mmwr.rr6901a1.
2
Simple Estimates for Local Prevalence of Latent Tuberculosis Infection, United States, 2011-2015.2011-2015 年美国潜伏性结核病感染的局部流行率简易估计。
Emerg Infect Dis. 2018 Oct;24(10):1930-1933. doi: 10.3201/eid2410.180716.
3
Update of Recommendations for Use of Once-Weekly Isoniazid-Rifapentine Regimen to Treat Latent Mycobacterium tuberculosis Infection.异烟肼-利福平每周方案治疗潜伏性结核分枝杆菌感染的推荐更新。
MMWR Morb Mortal Wkly Rep. 2018 Jun 29;67(25):723-726. doi: 10.15585/mmwr.mm6725a5.
4
Pyridoxine for the treatment of isoniazid-induced seizures in intentional ingestions: The experience of a national poison center.用于治疗故意摄入异烟肼所致癫痫发作的吡哆醇：一家国家中毒控制中心的经验
Am J Emerg Med. 2018 Oct;36(10):1775-1778. doi: 10.1016/j.ajem.2018.01.085. Epub 2018 Jan 31.
5
High Rate of Treatment Completion in Program Settings With 12-Dose Weekly Isoniazid and Rifapentine for Latent Mycobacterium tuberculosis Infection.在每周 12 剂量异烟肼和利福喷汀治疗潜伏性结核分枝杆菌感染的项目环境中，治疗完成率较高。
Clin Infect Dis. 2017 Oct 1;65(7):1085-1093. doi: 10.1093/cid/cix505.
6
The Selection and Use of Essential Medicines.基本药物的选择与使用
World Health Organ Tech Rep Ser. 2015(994):vii-xv, 1-546.
7
Treatment of drug-induced seizures.药物性癫痫发作的治疗。
Br J Clin Pharmacol. 2016 Mar;81(3):412-9. doi: 10.1111/bcp.12720. Epub 2015 Sep 17.
8
Isoniazid induced convulsions at therapeutic dose in an alcoholic and smoker patient.异烟肼在一名酗酒且吸烟的患者中，以治疗剂量诱发了惊厥。
Curr Drug Saf. 2015;10(1):94-5. doi: 10.2174/1574886309666140930151343.
9
Convulsive seizures with a therapeutic dose of isoniazid.使用治疗剂量异烟肼引发的惊厥性癫痫发作。
Intern Med. 2014;53(3):239-42. doi: 10.2169/internalmedicine.53.1303.
10
Seizures with single therapeutic dose of isoniazid.单次治疗剂量异烟肼所致癫痫发作
Indian J Tuberc. 2012 Apr;59(2):100-2.

免疫功能正常的成年人因潜伏性结核感染治疗而发生癫痫发作：是异烟肼的责任吗？

Seizures in an Immunocompetent Adult From Treatment of Latent Tuberculosis Infection: Is Isoniazid to Blame?

作者信息

Navalkele Bhagyashri, Bueno Rios Maria X, Wofford John D, Kumar Vijay, Webb Risa M

机构信息

University of Mississippi Medical Center, Jackson, Mississippi, USA.

出版信息

Open Forum Infect Dis. 2020 Apr 23;7(5):ofaa144. doi: 10.1093/ofid/ofaa144. eCollection 2020 May.

DOI:10.1093/ofid/ofaa144
PMID:32462048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7237819/
Abstract

Isoniazid-induced seizures are a rare adverse reaction especially in immunocompetent adults. We report a case of a healthy man with seizures shortly after ingestion of his first therapeutic dose of isoniazid with rifapentine therapy for treatment of latent tuberculosis infection. Only 6 other similar cases are reported in the literature.

摘要

异烟肼诱发的癫痫发作是一种罕见的不良反应，尤其在免疫功能正常的成年人中。我们报告一例健康男性在首次服用治疗剂量的异烟肼联合利福喷汀治疗潜伏性结核感染后不久出现癫痫发作的病例。文献中仅报道了其他6例类似病例。