Doellman Mary, Chen Philip G, McMains Kevin C, Sarber Kathleen M, Weitzel Erik K
Department of Otolaryngology - Head and Neck Surgery, San Antonio Military Medical Center, Fort Sam, Houston, Texas, USA.
Allergy Rhinol (Providence). 2015 Jan;6(1):8-11. doi: 10.2500/ar.2015.6.0115.
Allergic fungal sinusitis (AFS) is a stubborn disease requiring surgical and medical management. Delivery of topical medication is paramount in these patients, but the most difficult to accomplish. We investigated heavy irrigation (nasal douche) and atomized medication delivery potential in a cadaveric sinus model of polypoid AFS disease. Three disease models were created: a control that involved unoperated sinuses and no simulated disease; an unoperated AFS with type II polyposis mode; and an operated model with recurrent allergic fungal sinusitis with type II polyposis. The maxillary sinus showed the best irrigation and overall the heavy irrigator was more efficient than the atomizer.
变应性真菌性鼻窦炎（AFS）是一种需要手术和药物治疗的顽固性疾病。局部用药对这些患者至关重要，但也是最难实现的。我们在息肉样AFS疾病的尸体鼻窦模型中研究了大量冲洗（鼻腔灌洗）和雾化给药的可能性。创建了三种疾病模型：一种是涉及未手术鼻窦且无模拟疾病的对照模型；一种是II型息肉病模式的未手术AFS模型；以及一种复发性变应性真菌性鼻窦炎伴II型息肉病的手术模型。上颌窦显示出最佳的冲洗效果，总体而言，大量冲洗器比雾化器更有效。
