正常肌肉结构、生长、发育及再生。
Normal muscle structure, growth, development, and regeneration.
作者信息
de Rezende Pinto Wladimir Bocca Vieira, de Souza Paulo Victor Sgobbi, Oliveira Acary Souza Bulle
机构信息
Division of Neuromuscular Diseases, Department of Neurology and Neurosurgery, Federal University of São Paulo (UNIFESP), Estado de Israel Street, 899. Vila Clementino, São Paulo, SP, 04022-002, Brazil,
出版信息
Curr Rev Musculoskelet Med. 2015 Jun;8(2):176-81. doi: 10.1007/s12178-015-9267-x.
Knowledge about biochemical, structural and physiological aspects, and properties regarding the skeletal muscle has been widely obtained in the last decades. Muscle disorders, mainly represented in neuromuscular clinical practice by acquired and hereditary myopathies, are well-recognized and frequently diagnosed in practice. Most clinical complaints and biochemical characterizations of each myopathy depends on the appropriate knowledge and interpretation of pathological findings and their comparison with normal muscle findings. Great improvement has been obtained in the last decades mainly involving the mechanisms of normal muscle architecture and physiological function in the healthy individuals. Genetic mechanisms have also been widely studied. We provide an extensive literature review involving current knowledge regarding muscle cell structure and function and embryological and regenerative processes linked to muscle lesion. An updated comprehensive description involving the main nuclear genomic regulatory mechanisms of muscle regeneration and embryogenesis is provided in this review.
在过去几十年中，人们已广泛获取了有关骨骼肌的生化、结构和生理方面以及特性的知识。肌肉疾病在神经肌肉临床实践中主要表现为获得性和遗传性肌病，已得到充分认识且在实践中经常被诊断出来。每种肌病的大多数临床症状和生化特征取决于对病理结果的适当了解和解读，以及将其与正常肌肉结果进行比较。在过去几十年中取得了巨大进展，主要涉及健康个体中正常肌肉结构和生理功能的机制。遗传机制也得到了广泛研究。我们提供了一篇广泛的文献综述，涉及有关肌肉细胞结构和功能以及与肌肉损伤相关的胚胎学和再生过程的当前知识。本综述提供了关于肌肉再生和胚胎发生的主要核基因组调控机制的最新全面描述。
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