Yang Da-Song, Li Zi-Lei, Peng Wei-Bing, Yang Yong-Ping, Wang Xue, Liu Ke-Chun, Li Xiao-Li, Xiao Wei-Lie
Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Germplasm Bank of Wild Species in Southwest China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
Biology Institute of Shandong Academy of Sciences, Jinan 250014, PR China.
Fitoterapia. 2015 Jun;103:165-70. doi: 10.1016/j.fitote.2015.04.001. Epub 2015 Apr 8.
One rare flavonoid-diterpene heterodimer, denticulatain C (1), one modified geranyl-type side chain substituted flavonoid, denticulatain D (2) and one geranylated flavonoid, denticulatain E (3), as well as 11 known compounds (4-14) were isolated from the fronds of Macaranga denticulata. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 4 and 8 inhibited the proliferation of A-549 cell line with IC50 values of 48.6 and 20.2 μg/mL, respectively. Compounds 3, 6, and 8 exhibited significant antiangiogenic activity on a zebrafish model with IC50 values of 9.78, 0.34, and 2.55 μg/mL, respectively.
从齿叶血桐的叶片中分离出一种罕见的黄酮类-二萜类杂二聚体——齿叶血桐素C（1）、一种带有修饰香叶基型侧链取代的黄酮类化合物——齿叶血桐素D（2）、一种香叶基化黄酮类化合物——齿叶血桐素E（3），以及11种已知化合物（4 - 14）。通过广泛的光谱解析阐明了它们的结构。化合物4和8抑制A - 549细胞系的增殖，IC50值分别为48.6和20.2 μg/mL。化合物3、6和8在斑马鱼模型上表现出显著的抗血管生成活性，IC50值分别为9.78、0.34和2.55 μg/mL。
