Yang Da-Song, Wei Jian-Guo, Peng Wei-Bing, Wang Shuang-Mei, Sun Chen, Yang Yong-Ping, Liu Ke-Chun, Li Xiao-Li
Key Laboratory of Economic Plants and Biotechnology; Germplasm Bank of Wild Species in Southwest China; Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
Biology Institute of Shandong Academy of Sciences, Jinan 250014, PR China.
Fitoterapia. 2014 Dec;99:261-6. doi: 10.1016/j.fitote.2014.10.003. Epub 2014 Oct 14.
One unique prenylated bibenzyl, kurzphenol A (1), two new prenylated flavonoids, kurzphenols B and C (2 and 3), as well as fourteen known compounds (4-17) were isolated from the twigs of Macaranga kurzii. Compound 1 was the first example of prenylated bibenzyl which possesses a benzofuran ring. All the known compounds were isolated from M. kurzii for the first time. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 1-17 were tested for their cytotoxicity against A-549 and Hep G2 cancer cell lines and showed IC50 values in the range of 9.76-30.14 μg/mL.
从红背桂的嫩枝中分离出一种独特的异戊烯基联苄，即红背桂酚A（1）、两种新的异戊烯基黄酮，红背桂酚B和C（2和3），以及十四种已知化合物（4 - 17）。化合物1是具有苯并呋喃环的异戊烯基联苄的首个实例。所有已知化合物均首次从红背桂中分离得到。通过广泛的光谱解析阐明了它们的结构。测试了化合物1 - 17对A - 549和Hep G2癌细胞系的细胞毒性，其半数抑制浓度（IC50）值在9.76 - 30.14μg/mL范围内。
