Toyosaka A, Okamoto E, Okasora T, Nose K, Nakai Y, Tomimoto Y, Muraji T
First Department of Surgery of Hyogo College of Medicine, Nishinomiya, Japan.
Nihon Geka Gakkai Zasshi. 1989 Sep;90(9):1348-52.
The late complications in 25 patients more than 3 years after successful Kasai's operation for biliary atresia were presented. Nine (36%) of these 25 patients had episodes of variceal hemorrhage with portal hypertension, and biliary reobstruction in 3 (12%), bleeding from duodenal ulcer in 2, bleeding from gastric erosion in one, and diffuse pulmonary arterio-venous shunt in one were observed. Recently esophageal varices have been well controlled by endoscopic sclerotherapy, and the surgical treatment may be indicated in older children complicated with severe hypersplenism and marked splenomegaly, which are resistant for sclerotherapy. As a surgical procedure, splenectomy with periesophago-gastric devascularization (Hassab's operation) seems to be very useful for portal hypertension by biliary cirrhosis. The reoperation, hepaticoenterostomy, was performed in 3 patients with biliary reobstruction. All three patients are alive and well, and two of them are at 19 years (university student) and 24 years (married life) of age. Hepatic Rehepaticoenterostomy is well indicated rather than liver transplantation, if biliary reobstruction is incurable with conservative therapy. Many of the patients with complications were able to carry on an almost normal life, if suitable treatments for complications were taken.
本文报告了25例胆道闭锁患者在成功接受Kasai手术后3年以上出现的晚期并发症。这25例患者中,9例(36%)发生门静脉高压性静脉曲张出血,3例(12%)出现胆道再梗阻,2例出现十二指肠溃疡出血,1例出现胃黏膜糜烂出血,1例出现弥漫性肺动静脉分流。近来,内镜硬化治疗已能很好地控制食管静脉曲张,对于年龄较大、合并严重脾功能亢进和明显脾肿大且硬化治疗无效的患儿,可能需要进行手术治疗。作为一种手术方法,脾切除加食管胃周去血管化(Hassab手术)似乎对胆汁性肝硬化所致门静脉高压非常有效。3例胆道再梗阻患者接受了再次手术,即肝肠吻合术。所有3例患者均存活且情况良好,其中2例分别为19岁(大学生)和24岁(已婚)。如果保守治疗无法治愈胆道再梗阻,肝再次肝肠吻合术比肝移植更适用。如果对并发症采取适当的治疗措施,许多有并发症的患者能够过上几乎正常的生活。