Chen Xiao-Tao, Tan Jing-Yi, Lei Li-Hong, Chen Li-Li
Am J Dent. 2015 Feb;28(1):9-12.
To evaluate the Th1/Th2/Th17 cytokine levels in plasma and gingival crevicular fluid (GCF) from chronic periodontitis patients and healthy controls.
The concentration of interleukin-2 (IL-2), IL-4, IL-6, IL-10, IL-17, TNF, and IFN-γ were determined using a flow cytometric multiplex immunoassay (CBA), and was compared between the periodontitis group and the healthy group. Spearman rho coefficient was used to correlate cytokines in GCF in the periodontitis group and the healthy group, respectively.
Comparisons of two groups of Th1/Th2/Th17 cytokine levels in plasma and GCF showed no statistically significant differences (P > 0.05), except Th17 (IL-17) level in plasma that was higher in the periodontitis group than the healthy group (P < 0.05). A stronger correlation between IL-17/IL-4 and IL-17/IL-10 was observed in periodontitis patients than in healthy controls.
评估慢性牙周炎患者和健康对照者血浆及龈沟液（GCF）中Th1/Th2/Th17细胞因子水平。
采用流式细胞术多重免疫测定法（CBA）测定白细胞介素-2（IL-2）、IL-4、IL-6、IL-10、IL-17、肿瘤坏死因子（TNF）和干扰素-γ（IFN-γ）的浓度，并在牙周炎组和健康组之间进行比较。分别用Spearman秩相关系数分析牙周炎组和健康组龈沟液中细胞因子之间的相关性。
两组血浆和龈沟液中Thl/Th2/Th17细胞因子水平比较，差异均无统计学意义（P>0.05），但牙周炎组血浆中Th17（IL-17）水平高于健康组（P<0.05）。与健康对照者相比，牙周炎患者IL-17/IL-4和IL-17/IL-10之间的相关性更强。
