da Silva Felipe Rodolfo Pereira, Galeno Juliana Gomes, Leal Alessandro Luiz Araújo Bentes, Koga Reyce Santos, Batista Nayana Yared, da Conceição Furtado Silvânia, Vasconcelos Daniel Fernando Pereira, Carvalho Marcelo Diniz, Barcellos José Fernando Marques
Doctorate Post-Graduation Program in Basic and Applied Immunology, Federal University of Amazonas, Manaus, Amazonas, Brazil.
Department of Morphology, Federal University of Amazonas, General Rodrigo Octavio Jordão Ramos Avenue, 1200, Coroado, Manaus, Amazonas, CEP: 69067-005, Brazil.
BMC Oral Health. 2020 Feb 19;20(1):58. doi: 10.1186/s12903-020-1034-8.
Chronic periodontitis (CP) is an immune-inflammatory disease that promotes tissue damage around the teeth. Among the several inflammatory mediators that orchestrate the periodontitis, there is the interleukin (IL)-2. Genetic variations in IL2 gene may be associated with the risk and severity of the disease. Contrary results are available in the literature with inconclusive findings and none meta-analysis to gather these data.
A literature search was performed for studies published before June 11, 2019 in diverse scientific and educational databases. The data was extracted by two investigators and the statistical evaluation was performed by Review Manager statistical program with heterogeneity (I) and Odds Ratio (OR) with 95% of Confidence Intervals (CI) calculations and a sensitive analysis to assess the accuracy of the obtained results. The publication bias was evaluated by Begg' and Egger's test with Comprehensive meta-analysis software. The value of P < 0.05 was considered as significant.
Five studies were identified in diverse ethnical groups with 1425 participants. The - 330 T/G polymorphism in IL2 gene was not significantly associated with CP in allelic evaluation (P > 0.05) as well as in the genotypic comparisons (P = 0.15). The Begg's test and the linear regression Egger's test did not show any evidence of publication bias risk (P > 0.05) which was corroborated by the absence of obvious asymmetry in Funnel plot graphic.
This meta-analysis showed a non-significant association between - 330 T/G polymorphism in IL2 gene and CP in any allelic evaluation.
慢性牙周炎（CP）是一种促进牙齿周围组织损伤的免疫炎症性疾病。在协调牙周炎的几种炎症介质中，有白细胞介素（IL）-2。IL2基因的遗传变异可能与该疾病的风险和严重程度相关。文献中存在相互矛盾的结果，研究结果尚无定论，且没有荟萃分析来收集这些数据。
在各种科学和教育数据库中检索2019年6月11日之前发表的研究。由两名研究人员提取数据，并使用Review Manager统计程序进行统计评估，计算异质性（I）和比值比（OR）以及95%置信区间（CI），并进行敏感性分析以评估所得结果的准确性。使用综合荟萃分析软件通过Begg检验和Egger检验评估发表偏倚。P值<0.05被认为具有统计学意义。
在不同种族群体中确定了五项研究，共有1425名参与者。在等位基因评估（P>0.05）以及基因型比较（P=0.15）中，IL2基因的-330T/G多态性与慢性牙周炎无显著相关性。Begg检验和线性回归Egger检验均未显示发表偏倚风险的任何证据（P>0.05），漏斗图中没有明显的不对称性也证实了这一点。
这项荟萃分析表明，在任何等位基因评估中，IL2基因的-330T/G多态性与慢性牙周炎之间无显著相关性。
