Jiang N, Liu Q, Liu L, Yang W W, Zeng Y
Clin Exp Obstet Gynecol. 2015;42(1):79-81.
Pregnant women with chronic hypertension are at increased risk for complications. This study aims to investigate whether calcium channel blockers plus low dosage aspirin therapy can reduce the incidence of complications during pregnancy with chronic hypertension and improve the prognosis of neonates.
From March 2011 to June 2013, 33 patients were selected to join this trial according to the chronic hypertension criteria set by the Preface Bulletin of American College of Obstetricians and Gynecologists, (ACOG). Patients were administrated calcium channel blockers plus low-dosage aspirin and vitamin C. The statistic data of baseline and prognosis from the patients were retrospectively reviewed and compared.
Blood pressure of patients was controlled by these medicines with average systolic pressure from 146.3 to 148.7 mmHg and average diastolic pressure from 93.8 to 97.9 mmHg; 39.4% patients complicated mild preeclampsia; however, none of them developed severe preeclampsia or eclampsia, or complicate placental abruption. 30.3% patients delivered at preterm labour; 84.8% patients underwent cesarean section. The neonatal average weight was 3,008 ± 629.6 g, in which seven neonatal weights were less than 2,500 g. All of the neonatal Apgar scores were 9 to 10 at one to five minutes. Small for gestational age (SGA) occurred in five (15%).
Calcium channel blockers can improve the outcome of pregnancy women with chronic hypertension to avoid the occurrence of severe pregnancy complication or neonatal morbidity.
患有慢性高血压的孕妇出现并发症的风险增加。本研究旨在调查钙通道阻滞剂加小剂量阿司匹林治疗是否能降低慢性高血压孕妇孕期并发症的发生率并改善新生儿预后。
根据美国妇产科医师学会（ACOG）前言公告设定的慢性高血压标准，选取2011年3月至2013年6月期间的33例患者参加本试验。患者接受钙通道阻滞剂加小剂量阿司匹林和维生素C治疗。对患者的基线和预后统计数据进行回顾性分析和比较。
这些药物控制了患者的血压，平均收缩压为146.3至148.7mmHg，平均舒张压为93.8至97.9mmHg；39.4%的患者并发轻度先兆子痫；然而，他们均未发生重度先兆子痫或子痫，也未并发胎盘早剥。30.3%的患者早产；84.8%的患者接受剖宫产。新生儿平均体重为3008±629.6g，其中7例新生儿体重低于2500g。所有新生儿1至5分钟时的阿氏评分均为9至10分。小于胎龄儿（SGA）发生率为5例（15%）。
钙通道阻滞剂可改善慢性高血压孕妇的妊娠结局，避免发生严重妊娠并发症或新生儿发病。
