Hou Lifei, Wang Tian, Sun Jiaren
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-1070, USA.
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-1070, USA.
Int Immunopharmacol. 2015 Oct;28(2):887-91. doi: 10.1016/j.intimp.2015.03.038. Epub 2015 Apr 10.
Standing at the interface of innate and adaptive immune, γδ T cells play important pathophysiologic roles in infection, autoimmunity, and tumorigenesis. Recent studies indicate that γδ T cells could be categorized into IFN-γ(+) and IL-17(+) subsets, both of which possess select TCR usages, bear unique surface markers and require different cytokine signaling to maintain the homeostasis. In addition, as the major innate IL-17 producers, γδ T cells are increasingly appreciated for their involvement in various acute infections and injuries. This review will summarize the characteristics of IFN-γ(+) (γδ T-IFN-γ) and IL-17(+) γδ T cells (γδT17) and discuss their distinct pathogenic functions in different disease models.
γδ T细胞处于固有免疫和适应性免疫的交界处，在感染、自身免疫和肿瘤发生中发挥重要的病理生理作用。最近的研究表明，γδ T细胞可分为IFN-γ(+)和IL-17(+)亚群，这两个亚群都有特定的TCR使用情况，具有独特的表面标志物，并且需要不同的细胞因子信号来维持体内平衡。此外，作为主要的固有IL-17产生细胞，γδ T细胞因其参与各种急性感染和损伤而越来越受到重视。本综述将总结IFN-γ(+)（γδ T-IFN-γ）和IL-17(+) γδ T细胞（γδT17）的特征，并讨论它们在不同疾病模型中的不同致病功能。
